However, in our case series, the role of C. Asthma Triggers Exposure History. Effects of dexamethasone on rhinovirus infection in cultured human tracheal epithelial cells. The relationship of rhinovirus-associated asthma hospitalizations with inhaled corticosteroids and smoking. The association of Chlamydia pneumoniae infection and reactive airway disease in children. Pathogenic bacteria and viruses in induced sputum or pharyngeal secretions of adults with stable asthma. A recent study showed that C.

Whilst serology is an indirect measure of infection, direct detection of C. The first step in dealing with the asthma patient is to make sure it is asthma. Our data suggest an association between AAI and the severity of acute asthma attack. In fact, we found C. Factors associated with acute health care use in a national adult asthma management program. Reproduced, with permission, from Fahy [ ]. The Th1 cytokines induced by rhinovirus infection during acute asthma differ from the production of Th2 cytokines more typical of chronic asthma IL-4, IL-5, IL [ 72 ].

case study aeba

In every patient peak expiratory flow PEF measurement was performed on admission, and spirometry during follow-up. Respiratory viruses and exacerbations of asthma in adults. According to the latest NIH National Asthma Education and Prevention Guidelines, asthma exacerbations are acute or subacute episodes of progressively worsening shortness of breath, cough, wheezing, and chest tightness, or some combination of these symptoms, characterized by decreases in expiratory airflow and objective measures of lung function spirometry and peak flow [ 6 ].

To our knowledge, no studies have evaluated the relationship between these two atypical bacteria and the severity of functional impairment during AEBA. Pan-viral screening of respiratory tract infections in adults with and without asthma reveals unexpected human coronavirus and human rhinovirus diversity.

However, for the diagnosis of C.

Acute Exacerbations of Asthma: Epidemiology, Biology and the Exacerbation-Prone Phenotype

The public health burden of chronic asthma has increased over the past two decades, and acute exacerbations of asthma are a particularly important and costly problem. Patients with a radiological diagnosis of pneumonia or with impaired consciousness on admission were excluded from the study.


RC takes responsibility for the paper as a whole. The relationship between FEV1 and risk of asthma exacerbation could be because exacerbations cause or promote long term reductions in lung function or alternatively, the relationship may be a result of specific types of airway inflammation or specific host factors, such as smoking, that increase the risk of both exacerbation and lung function decline.

case study aeba

However, to date the relationship between acute atypical infection AAI and the degree of severity of acute asthma exacerbation has not been yet evaluated. Another important modifiable risk factor in this study was exposure and allergic sensitivity to cat or dog, further underscoring the interaction between allergic and viral causes. Role of persistent infection in the control and severity of asthma: Inasthma exacerbations resulted in Competing interests The authors declare that they have no competing interests.

Asthma exacerbations and sputum eosinophil counts: Trends in Asthma Morbidity and Mortality. Serologic evidence of single acute M. Interleukin gene expression in acute virus-induced asthma. Should the association between AAI and severity of asthma exacerbation be confirmed in larger case series, appropriate anti-atypical bacterial antibiotic treatment may have to be considered in patients with severe asthma exacerbations.

Taking into account the limited population size in the study, acse data should be confirmed by further studies. RC provided statistical advice on study design and analyzed the data. Low dose inhaled budesonide and formoterol in mild persistent asthma: It is clear that a subset of asthmatics is particularly susceptible to recurrent exacerbations.


Acute Exacerbations of Asthma: Epidemiology, Biology and the Exacerbation-Prone Phenotype

Skip directly to search Skip directly to A to Z list Skip directly to site content. Fifty-eight patients have been enrolled.

In the Unites States, the prevalence of self-reported asthma exacerbation is particularly high among Americans of Puerto-Ricans ancestry which is in contrast ztudy a relatively low frequency of asthma exacerbation in other Hispanic subgroups such as Mexican Americans [ 8 ]. J Gen Intern Med.

These effects persisted up to one month following the infection and were not observed in non-atopic subjects. Infection of airway epithelial cells with rhinovirus causes the release of pro-inflammatory cytokines and chemokines, as well as recruitment of inflammatory cells, particularly neutrophils, lymphocytes, and eosinophils.

This deficiency was observed whether or not asthmatics were taking inhaled corticosteroids. Pathogenic bacteria and viruses in induced sputum or pharyngeal secretions of adults with stable asthma. Characteristic features of the exacerbation prone subjects include irreversible airflow limitation, chronic sinusitis, psychological dysfunction, and intolerance to non-steroidal anti-inflammatory medications [ 3132 ]. The purpose of this review is to examine the epidemiologic features of acute asthma exacerbations and to summarize recent advances in our understanding of the clinical and biological features of asthma exacerbations.

Data from the U. Notably, a significant percentage of asthmatics had multiple exacerbations requiring three or more bursts of oral corticosteroids per year ranging across all levels of severity: Int Arch Allergy Immunol.